CYP2D6 genotype dependent oxycodone metabolism in postoperative patients.

doi:10.1371/journal.pone.0060239

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Article

CYP2D6 genotype dependent oxycodone metabolism in postoperative patients.

PloS one - 1 Jan 2013

Stamer Ulrike M, Zhang Lan, Book Malte, Lehmann Lutz E, Stuber Frank, Musshoff Frank

Abstract excerpt

BACKGROUND: The impact of polymorphic cytochrome P450 CYP2D6 enzyme on oxycodone's metabolism and clinical efficacy is currently being discussed. However, there are only spare data from postoperative settings. The hypothesis of this study is that genotype dependent CYP2D6 activity influences plasma concentrations of oxycodone and its metabolites and impacts analgesic consumption. METHODS: Patients received...

Topics

Aged
Analgesics, Opioid
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Female
Genotype
Humans
Male
Middle Aged
Morphinans
Oxycodone
Oxymorphone
Spectrometry, Mass, Electrospray Ionization

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Identifiers

PMID: 23555934
DOI: 10.1371/journal.pone.0060239
PMCID: PMC3610662

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