Article
Clinical application of pharmacogenetics in pain management.
Personalized medicine - 1 Mar 2018
Smith D Max, Weitzel Kristin W, Cavallari Larisa H, Elsey Amanda R, Schmidt Siegfried Of
Abstract excerpt
There is growing experience translating genomic data into clinical practice, as seen with the Implementing GeNomics In pracTicE (IGNITE) network. A primary example is the influence of CYP2D6 genotype on the beneficial and adverse effects of some opioids. Clinical recommendations exist to guide drug therapy based on CYP2D6 genotype for codeine, tramadol, oxycodone and hydrocodone, although the level of supporting...
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