Article
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Clinical pharmacology and therapeutics - 1 Oct 2021
Crews Kristine R, Monte Andrew A, Huddart Rachel, Caudle Kelly E, Kharasch Evan D, Gaedigk Andrea, Dunnenberger Henry M, Leeder J Steven, Callaghan John T, Samer Caroline Flora, Klein Teri E, Haidar Cyrine E, Van Driest Sara L, Ruano Gualberto, Sangkuhl Katrin, Cavallari Larisa H, Müller Daniel J, Prows Cynthia A, Nagy Mohamed, Somogyi Andrew A, Skaar Todd C
Abstract excerpt
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone). Polymorphisms in CYP2D6 have been studied for an association with the clinical effect and safety of these drugs. Other genes that have been studied for their association with opioid clinical effect or adverse events include OPRM1 (mu...
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