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Article

Evolutionary Mechanisms of Cancer Suggest Rational Therapeutic Approaches.

Cytogenetic and genome research - 1 Jan 2021

Balzerano Alessio, Paccosi Elena, Proietti-De-Santis Luca

Abstract excerpt

The goal in personalized therapeutic approaches for cancer medicine is to identify specific mutations with prognostic and therapeutic value in order to tailor the therapy for the single patient. The most powerful obstacle for personalized medicine arises from intratumor heterogeneity and clonal evolution, which can promote drug resistance. In this scenario, new technologies, such as next-generation sequencing,...

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PMID: 34461614
DOI: 10.1159/000516530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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