Article
Transcriptional control of a novel long noncoding RNA Mymsl in smooth muscle cells by a single Cis-element and its initial functional characterization in vessels.
Journal of molecular and cellular cardiology - 1 Jan 2020
Choi Mihyun, Lu Yao Wei, Zhao Jinjing, Wu Mingfu, Zhang Wei, Long Xiaochun
Abstract excerpt
Differentiated vascular smooth muscle cells (VSMCs) are crucial in maintaining vascular homeostasis. While the coding transcriptome of the differentiated VSMC phenotype has been defined, we know little about its noncoding signature. Herein, we identified a Myocardin-induced muscle specific long noncoding RNA (lncRNA) (Mymsl) downregulated upon VSMC phenotypic modulation. We demonstrated an essential role of a...
Topics
- Animals
- Aorta
- Blood Vessels
- Cell Differentiation
- Down-Regulation
- Extracellular Matrix
- Gene Editing
- Genome
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation