Article
CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean G6PD Variant.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2020
Kitagawa Atsushi, Kizub Igor, Jacob Christina, Michael Kevin, D'Alessandro Angelo, Reisz Julie A, Grzybowski Michael, Geurts Aron M, Rocic Petra, Gupte Rakhee, Miano Joseph M, Gupte Sachin A
Abstract excerpt
Epidemiological studies suggest that individuals in the Mediterranean region with a loss-of-function, nonsynonymous single nucleotide polymorphism (S188F), in glucose-6-phosphate dehydrogenase (G6pd) are less susceptible to vascular diseases. However, this association has not yet been experimentally proven. Here, we set out to determine whether the Mediterranean mutation confers protection from vascular diseases...
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