Article

Studies in CRISPR-generated Mediterranean G6PD variant rats reveal G6PD orchestrates genome-wide DNA methylation and gene expression in vascular wall

2023-03-07

Abstract excerpt

<h4>Background</h4> Recent advances have revealed the importance of epigenetic modifications to gene regulation and transcriptional activity. DNA methylation, a determinant of genetic imprinting and de novo silencing of genes genome-wide, is known to be controlled by DNA methyltransferases (DNMT) and demethylases (TET) under disease conditions. However, the mechanism(s)/factor(s) influencing the expression and a...

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Literature Corpus work: 9fc9808b-d9f7-5599-819d-4685175d984f
DOI: 10.1101/2023.03.06.531429

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