Article
Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height.
eLife - 5 Dec 2017
Guo Michael, Liu Zun, Willen Jessie, Shaw Cameron P, Richard Daniel, Jagoda Evelyn, Doxey Andrew C, Hirschhorn Joel, Capellini Terence D
Abstract excerpt
GWAS have identified hundreds of height-associated loci. However, determining causal mechanisms is challenging, especially since height-relevant tissues (e.g. growth plates) are difficult to study. To uncover mechanisms by which height GWAS variants function, we performed epigenetic profiling of murine femoral growth plates. The profiled open chromatin regions recapitulate known chondrocyte and skeletal biology,...
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