Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated transcriptomic and functional analysis reveals tissue-specific molecular pathology in adolescent idiopathic scoliosis.

HGG advances - 9 Jul 2026

Ramkhalawan Darius, Parrales Paola, Koesterich Justin, Montoya-Vazquez Gloria, Cuna Carlos, Kreimer Anat, McQuerry Jessica, Ihnow Stephanie, Makki Nadja

Abstract excerpt

Adolescent idiopathic scoliosis (AIS), the spontaneous development of a lateral spine curvature during puberty, is the most common pediatric spine disorder, affecting ∼3% of children worldwide. As the underlying etiology remains unclear, AIS is treated purely symptomatically, initially by bracing and ultimately by highly invasive, costly surgeries. Genome-wide association studies (GWASs) have identified numerous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to EGR1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Scoliosis

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 42244182
DOI: 10.1016/j.xhgg.2026.100631
PMCID: PMC13316586

Genes

ADGRG6
BCL2
BNC2
EGR1
FTO
MYH1
SOX5
SOX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated transcriptomic and functional analysis reveals tissue-specific molecular pathology in adolescent idiopathic scoliosis.PMID 42244182Read ↗

Integrated Transcriptomic and Functional Analysis Reveals Tissue-Specific Molecular Pathology in Adolescent Idiopathic ScoliosisSemantic proximity Read ↗

Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome.Semantic proximity Read ↗

Genomic characterization of the adolescent idiopathic scoliosis associated transcriptome and regulomeSemantic proximity Read ↗

Whole Genome Sequencing in Adolescent Idiopathic Scoliosis Cohort Indicates Polygenic Disease Involving Multiple Biological PathwaysSemantic proximity Read ↗

Whole genome sequencing in adolescent idiopathic scoliosis cohort implicates multiple biological pathwaysSemantic proximity Read ↗

A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis.Semantic proximity Read ↗

Asymmetric expression of H19 and ADIPOQ in concave/convex paravertebral muscles is associated with severe adolescent idiopathic scoliosisSemantic proximity Read ↗

Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis.Semantic proximity Read ↗

Genetics and pathogenesis of scoliosisSemantic proximity Read ↗

Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls.Semantic proximity Read ↗

Massively parallel characterization of adolescent idiopathic scoliosis risk variantsSemantic proximity Read ↗

The Whole-Exome Sequencing of a Cohort of 19 Families with Adolescent Idiopathic Scoliosis (AIS): Candidate Pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.