Article
Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome.
Human molecular genetics - 21 Jan 2021
Makki Nadja, Zhao Jingjing, Liu Zhaoyang, Eckalbar Walter L, Ushiki Aki, Khanshour Anas M, Wu Joe, Rios Jonathan, Gray Ryan S, Wise Carol A, Ahituv Nadav
Abstract excerpt
Adolescent idiopathic scoliosis (AIS), a sideways curvature of the spine, is the most common pediatric musculoskeletal disorder, affecting ~3% of the population worldwide. However, its genetic bases and tissues of origin remain largely unknown. Several genome-wide association studies (GWAS) have implicated nucleotide variants in non-coding sequences that control genes with important roles in cartilage, muscle,...
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