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Article

Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2016

Mitchell Jonathan A, Chesi Alessandra, Elci Okan, McCormack Shana E, Roy Sani M, Kalkwarf Heidi J, Lappe Joan M, Gilsanz Vicente, Oberfield Sharon E, Shepherd John A, Kelly Andrea, Grant Struan Fa, Zemel Babette S

Abstract excerpt

Using adult identified bone mineral density (BMD) loci, we calculated genetic risk scores (GRS) to determine if they were associated with changes in BMD during childhood. Longitudinal data from the Bone Mineral Density in Childhood Study were analyzed (N = 798, 54% female, all European ancestry). Participants had up to 6 annual dual energy X-ray scans, from which areal BMD (aBMD) Z-scores for the spine, total...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26572781
DOI: 10.1002/jbmr.2744
PMCID: PMC4826827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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