Article
The role of dementia in the association between APOE4 and all-cause mortality: pooled analyses of two population-based cohort studies.
The lancet. Healthy longevity - 1 Jun 2024
Régy Mélina, Dugravot Aline, Sabia Séverine, Helmer Catherine, Tzourio Christophe, Hanseeuw Bernard, Singh-Manoux Archana, Dumurgier Julien
Abstract excerpt
BACKGROUND: The ε4 allele of the apolipoprotein E gene (APOE4) plays a role in neurodegeneration and in cardiovascular disease, but findings on its association with mortality are inconsistent. We aimed to examine the association between APOE4 and mortality, and the role of dementia in this association. METHODS: In this pooled analysis, data on White participants aged 45-90 years who underwent APOE genotyping were...
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