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How can elderly apolipoprotein E ε4 carriers remain free from dementia?

Neurobiology of aging - 1 Jan 2013

Ferrari Camilla, Xu Wei-Li, Wang Hui-Xin, Winblad Bengt, Sorbi Sandro, Qiu Chengxuan, Fratiglioni Laura

Abstract excerpt

Apolipoprotein E (APOE) ε4 is a major risk factor for Alzheimer's disease (AD) and dementia, but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in modifying the risk of dementia due to ε4. A cognitively intact cohort (n = 932, age ≥ 75) was followed for 9 years to detect incident dementia cases. At baseline, information on education, leisure activities, and vascular risk...

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Identifiers

PMID: 22503000
DOI: 10.1016/j.neurobiolaging.2012.03.003

Genes

APOE

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