Article
PIK3CA somatic alterations in invasive breast cancers: different spectrum from Caucasians to Chinese detected by next generation sequencing.
Breast cancer (Tokyo, Japan) - 1 May 2021
Jia Minghan, Liao Ning, Chen Bo, Zhang Guochun, Wang Yulei, Li Xuerui, Cao Li, Mok Hsiaopei, Ren Chongyang, Li Kai, Li Cheukfai, Wen Lingzhu, Lin Jiali, Wei Guangnan, Balch Charles M
Abstract excerpt
PURPOSE: Somatic alteration of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) is a crucial therapeutic target in breast cancer (BC) and PI3Kα-specific inhibitor Alpelisib has been used in clinics. This study investigates the PIK3CA alterations in Chinese and Caucasians BC patients for the purpose of selecting anti-PI3K therapy. METHODS: The molecular profile of the PIK3CA gene was...
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