Article
Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase.
PloS one - 1 Jan 2020
Jané Pau, Gógl Gergő, Kostmann Camille, Bich Goran, Girault Virginie, Caillet-Saguy Célia, Eberling Pascal, Vincentelli Renaud, Wolff Nicolas, Travé Gilles, Nominé Yves
Abstract excerpt
Protein domains often recognize short linear protein motifs composed of a core conserved consensus sequence surrounded by less critical, modulatory positions. PTEN, a lipid phosphatase involved in phosphatidylinositol 3-kinase (PI3K) pathway, contains such a short motif located at the extreme C-terminus capable to recognize PDZ domains. It has been shown that the acetylation of this motif could modulate the...
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