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Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy

2 Mar 2023

Abstract excerpt

Post-translational modifications (PTMs) regulate all aspects of protein function. Therefore, upstream regulators of PTMs, such as kinases, acetyltransferases, or methyltransferases, are potential therapeutic targets for human diseases, including cancer. To date, multiple inhibitors and/or agonists of these PTM upstream regulators are in clinical use, while others are still in development. However, these upstream...

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PMID: 36870680
DOI: 10.1016/j.jbc.2023.104572

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