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Article

Membrane-binding and activation mechanism of PTEN.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003

Das Sudipto, Dixon Jack E, Cho Wonhwa

Abstract excerpt

PTEN is a tumor suppressor that reverses the action of phosphoinositide 3-kinase by catalyzing the removal of the 3' phosphate of phosphoinositides. Despite the critical role of PTEN in cell signaling and regulation, the mechanisms of its membrane recruitment and activation is still poorly unders...

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Source

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Identifiers

PMID: 12808147
DOI: 10.1073/pnas.0932835100
PMCID: PMC164614

Genes

PTEN
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12808147-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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