Article

Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins

2020-06-21

Abstract excerpt

<h4>ABSTRACT</h4> Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs), but specific interaction with and regulation by PIPs for most PH domain-containing proteins are unclear. Here we employed a single-molecule pulldown assay to study interactions of lipid vesicles with full-length proteins in mammalian whole cell lysates. Of 67 human PH domaincontaining proteins examined, 36 (54%) were...

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Literature Corpus work: f1faaf2a-a8dc-5801-97c2-2d454fc1deb9
DOI: 10.1101/2020.06.20.163253

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