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Article

The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation.

The Journal of biological chemistry - 1 Jun 2023

Khella Mina S, Schnee Philipp, Weirich Sara, Bui Tan, Bröhm Alexander, Bashtrykov Pavel, Pleiss Jürgen, Jeltsch Albert

Abstract excerpt

Protein lysine methyltransferases (PKMTs) play essential roles in gene expression regulation and cancer development. Somatic mutations in PKMTs are frequently observed in cancer cells. In biochemical experiments, we show here that the NSD1 mutations Y1971C, R2017Q, and R2017L observed mostly in solid cancers are catalytically inactive suggesting that NSD1 acts as a tumor suppressor gene in these tumors. In...

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Identifiers

PMID: 37150325
DOI: 10.1016/j.jbc.2023.104796
PMCID: PMC10244704

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