Article
RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.
Molecular cell - 3 Aug 2017
Dungrawala Huzefa, Bhat Kamakoti P, Le Meur Rémy, Chazin Walter J, Ding Xia, Sharan Shyam K, Wessel Sarah R, Sathe Aditya A, Zhao Runxiang, Cortez David
Abstract excerpt
RAD51 promotes homology-directed repair (HDR), replication fork reversal, and stalled fork protection. Defects in these functions cause genomic instability and tumorigenesis but also generate hypersensitivity to cancer therapeutics. Here we describe the identification of RADX as an RPA-like, single-strand DNA binding protein. RADX is recruited to replication forks, where it prevents fork collapse by regulating...
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