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Article

DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects

20 Apr 2021

Abstract excerpt

Significance Replication stress can affect development and is a hallmark of cancers. Warsaw breakage syndrome is a developmental disorder caused by mutations in the conserved DDX11 DNA helicase. Here, using human cellular models of DDX11 deficiency, we report that DDX11 helicase prevents replication stress and mediates homology-directed repair via homologous recombination. Mechanistically, DDX11 promotes...

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PMID: 33879618
DOI: 10.1073/pnas.2024258118

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