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DNA2 drives processing and restart of reversed replication forks in human cells

2 Mar 2015

Abstract excerpt

Accurate processing of stalled or damaged DNA replication forks is paramount to genomic integrity and recent work points to replication fork reversal and restart as a central mechanism to ensuring high-fidelity DNA replication. Here, we identify a novel DNA2- and WRN-dependent mechanism of reversed replication fork processing and restart after prolonged genotoxic stress. The human DNA2 nuclease and WRN ATPase...

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CRISPR and Genetic Engineering
DNA Repair Mechanisms
PARP inhibition in cancer therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25733713
DOI: 10.1083/jcb.201406100

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