Article
Replication fork breakage and re-start: New insights into Rad3/XPD-associated deficiencies.
Cell cycle (Georgetown, Tex.) - 1 Aug 2010
Moriel-Carretero M, Aguilera A
Abstract excerpt
Failures in Nucleotide Excision Repair (NER) are generally associated with extreme sun sensitivity, high cancer risks and neurodegeneration. This is explained by the inability to repair UV lesions and oxidative damage, and may be ascribed to a deficiency in the TFIIH complex, which has a dual role in NER and transcription initiation. We have recently uncovered the molecular basis for a specific TFIIH component...
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