Article
Comparison of myeloid blast counts and variant allele frequencies of gene mutations in myelodysplastic syndrome with excess blasts and secondary acute myeloid leukemia.
Leukemia & lymphoma - 1 May 2021
Chen Xueyan, Othus Megan, Wood Brent L, Walter Roland B, Becker Pamela S, Percival Mary-Elizabeth, Abkowitz Janis L, Appelbaum Frederick R, Estey Elihu H
Abstract excerpt
Secondary acute myeloid leukemia (sAML) is biologically and clinically distinct from de novo AML and shares specific genetic mutations with myelodysplastic syndromes (MDS). We retrospectively analyzed data from 295 adults with MDS or AML with mutational analysis by next-generation sequencing (NGS), and examined differences in functional grouping of mutations and relation between morphologic blast count and...
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