Article

Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMML

2022-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Progressively acquired somatic mutations in hematopoietic stem cells are central to pathogenesis in myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). They can lead to proliferative advantages, impaired differentiation and progressive cytopenias. MDS or CMML patients with high-risk disease are treated with hypomethylating agents including 5-azacytidine (AZA). Clinical im...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 321059f8-4313-5dbf-b17e-c899a030ce25
DOI: 10.1101/2022.01.20.476890

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMMLDOI 10.1101/2022.01.20.476890Read

Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapySemantic proximity Read

Single-cell multi-omics of human clonal hematopoiesis reveals that <i>DNMT3A</i> R882 mutations perturb early progenitor states through selective hypomethylationSemantic proximity Read

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.Semantic proximity Read

Single cell multiomics reveal clonal and functional dynamics of MDS stem/progenitor cells during hypomethylating therapySemantic proximity Read

Immunophenotypic, cytogenetic, and mutational characterization of cell lines derived from myelodysplastic syndrome patients after progression to acute myeloid leukemia.Semantic proximity Read

Is it the time to integrate novel sequencing technologies into clinical practice?Semantic proximity Read

Single-cell mutational profiling enhances the clinical evaluation of AML MRD.Semantic proximity Read

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents.Semantic proximity Read

Design, implementation and clinical utility of next generation sequencing in myeloid malignancies: acute myeloid leukaemia and myelodysplastic syndrome.Semantic proximity Read

Single cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemiaSemantic proximity Read

Whole Exome Sequencing and Single-Cell DNA Sequencing for Assessment of Clonal Heterogeneity and Evolution in Acute Myeloid LeukemiaSemantic proximity Read

Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic SyndromesSemantic proximity Read