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Article

Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2014

Xu Lan, Gu Zhao-Hui, Li Yang, Zhang Jin-Li, Chang Chun-Kang, Pan Chun-Ming, Shi Jing-Yi, Shen Yang, Chen Bing, Wang Yue-Ying, Jiang Lu, Lu Jing, Xu Xin, Tan Jue-Ling, Chen Yu, Wang Sheng-Yue, Li Xiao, Chen Zhu, Chen Sai-Juan

Abstract excerpt

Myelodysplastic syndrome (MDS) includes a group of diseases characterized by dysplasia of bone marrow myeloid lineages with ineffective hematopoiesis and frequent evolution to acute myeloid leukemia (AML). Whole-genome sequencing was performed in CD34(+) hematopoietic stem/progenitor cells (HSPCs) from eight cases of refractory anemia with excess blasts (RAEB), the high-risk subtype of MDS. The nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24850867
DOI: 10.1073/pnas.1407688111
PMCID: PMC4060725

Genes

NPM1

Provenance

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