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Article

Clinical effect of point mutations in myelodysplastic syndromes.

The New England journal of medicine - 30 Jun 2011

Bejar Rafael, Stevenson Kristen, Abdel-Wahab Omar, Galili Naomi, Nilsson Björn, Garcia-Manero Guillermo, Kantarjian Hagop, Raza Azra, Levine Ross L, Neuberg Donna, Ebert Benjamin L

Abstract excerpt

BACKGROUND: Myelodysplastic syndromes are clinically heterogeneous disorders characterized by clonal hematopoiesis, impaired differentiation, peripheral-blood cytopenias, and a risk of progression to acute myeloid leukemia. Somatic mutations may influence the clinical phenotype but are not included in current prognostic scoring systems. METHODS: We used a combination of genomic approaches, including...

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Source

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Identifiers

PMID: 21714648
DOI: 10.1056/NEJMoa1013343
PMCID: PMC3159042

Genes

ETV6
RUNX1
ASXL1
GNAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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