Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro

4 Nov 2017

Abstract excerpt

AIM: The aim of this study was to study potential cytochrome P450 (CYP) induction by dicloxacillin. METHODS: We performed an open-label, randomized, two-phase, five-drug clinical pharmacokinetic cocktail crossover study in 12 healthy men with and without pretreatment with 1 g dicloxacillin three times daily for 10 days. Plasma and urine were collected over 24 h and the concentration of all five drugs and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics Pharmacokinetics and Efficacy
Share to Drug-Induced Hepatotoxicity and Protection
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29105855
DOI: 10.1111/bcp.13467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitroPMID 29105855Read ↗

A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes.Semantic proximity Read ↗

In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants.Semantic proximity Read ↗

An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.Semantic proximity Read ↗

Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study.Semantic proximity Read ↗

The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitro.Semantic proximity Read ↗

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2.Semantic proximity Read ↗

Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol.Semantic proximity Read ↗

Impact of Acute Inflammation on Cytochromes P450 Activity Assessed by the Geneva Cocktail.Semantic proximity Read ↗

Is diclofenac a valuable CYP2C9 probe in humans?Semantic proximity Read ↗

Analysis of diclofenac and its metabolites by high-performance liquid chromatography: relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios.Semantic proximity Read ↗

Development of the "Inje cocktail" for high-throughput evaluation of five human cytochrome P450 isoforms in vivo.Semantic proximity Read ↗

Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.