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Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Feb 2019

Palacharla Raghava Choudary, Molgara Parusharamulu, Panthangi Hanumanth Rao, Boggavarapu Rajesh Kumar, Manoharan Arun Kumar, Ponnamaneni Ranjith Kumar, Ajjala Devender Reddy, Nirogi Ramakrishna

Abstract excerpt

The objective is to evaluate methoxsalen as an in vitro phenotyping tool in comparison to ABT as a nonspecific inactivator of P450 mediated metabolism. The reversible inhibition of methoxsalen and ABT against the P450, FMO, AO, MAO-A and -B, enzymes were evaluated using standard marker probe reactions. The time-dependent inhibition of P450 enzymes was evaluated in human liver microsomes. CES1 activities were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29382249
DOI: 10.1080/00498254.2018.1434913

Genes

CES1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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