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Article

Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.

Clinical pharmacology and therapeutics - 1 Mar 2003

Chen Xiao-Ping, Tan Zhi-Rong, Huang Song-Lin, Huang Zheng, Ou-Yang Dong-Sheng, Zhou Hong-Hao

Abstract excerpt

OBJECTIVE: This study was designed to define the effect of low-dose aspirin administration on the activity of cytochrome P450 (CYP) in normal human subjects. METHODS: Aspirin, 50 mg daily, was given for 14 days to 18 nonsmoking healthy male volunteers. A modified 5-drug cocktail procedure consisting of caffeine, mephenytoin, metoprolol, chlorzoxazone, and midazolam was performed to simultaneously assess in vivo...

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Source

Identifiers

PMID: 12621391
DOI: 10.1067/mcp.2003.14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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