Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole.

Clinical pharmacology and therapeutics - 1 Sept 2007

Saussele T, Burk O, Blievernicht J K, Klein K, Nussler A, Nussler N, Hengstler J G, Eichelbaum M, Schwab M, Zanger U M

Abstract excerpt

The pyrazolone drug metamizole is a widely used analgesic. Analysis of liver microsomes from patients treated with metamizole revealed selectively higher expression of cytochromes P450, CYP2B6 and CYP3A4 (3.8- and 2.8-fold, respectively), and 2.9-fold higher bupropion hydroxylase activity compared with untreated subjects. Further investigation of metamizole and various derivatives on different potential target...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Constitutive Androstane Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

Share to Enzyme Induction

Share to Microsomes, Liver

Share to Oxidoreductases, N-Demethylating

Share to Pregnane X Receptor

Share to Receptors, Steroid

Source

Identifiers

PMID: 17344806
DOI: 10.1038/sj.clpt.6100138

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole.PMID 17344806Read ↗

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2.Semantic proximity Read ↗

Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men.Semantic proximity Read ↗

Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitroSemantic proximity Read ↗

Transcriptional Regulation of Cytochrome P450 2B Genes by Nuclear ReceptorsSemantic proximity Read ↗

Pregnane X receptor-mediated induction of Cyp3a by black cohoshSemantic proximity Read ↗

The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X ReceptorSemantic proximity Read ↗

In vivo metabolism of the new designer drug 1-(4-methoxyphenyl)piperazine (MeOPP) in rat and identification of the human cytochrome P450 enzymes responsible for the major metabolic step.Semantic proximity Read ↗

Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.Semantic proximity Read ↗

Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation.Semantic proximity Read ↗

Different Inductive Effects of Praziquantel Racemate and its Enantiomers on the Enzyme CYP3A4 Mediated by Pregnane X Receptor and its Variants.Semantic proximity Read ↗

Cytochrome p450 3A4 messenger ribonucleic acid induction by rifampin in human peripheral blood mononuclear cells: correlation with alprazolam pharmacokinetics.Semantic proximity Read ↗

Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac †.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.