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Article

Lessons learned from next-generation sequencing in head and neck cancer.

Head & neck - 1 Mar 2013

Loyo Myriam, Li Ryan J, Bettegowda Chetan, Pickering Curtis R, Frederick Mitchell J, Myers Jeffrey N, Agrawal Nishant

Abstract excerpt

Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next-generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in NOTCH1, a gene that had not previously been implicated in head and neck...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22907887
DOI: 10.1002/hed.23100
PMCID: PMC3715072

Genes

NOTCH1
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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