Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOTCH1 mutations as prognostic marker in oral squamous cell carcinoma.

Pathology, research and practice - 1 Jul 2021

Wu-Chou Yah-Huei, Hsieh Chia-Hsun, Liao Chun-Ta, Lin Yin-Ting, Fan Wen-Lang, Yang Cheng-Han

Abstract excerpt

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with poor prognosis. The dysregulation of Notch signaling pathway has been implicated in the OSCC tumorigenesis. However, the clinical implication of NOTCH1 mutation status in OSCC remains unelucidated. We extracted the NOTCH1 gene mutations from a whole exome sequencing dataset of 168 frozen OSCC tumor specimens and validated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Databases, Genetic
Share to Exome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mouth Neoplasms

Share to Predictive Value of Tests

Share to Prognosis

Share to Receptor, Notch1

Share to Squamous Cell Carcinoma of Head and Neck

Source

Identifiers

PMID: 33993060
DOI: 10.1016/j.prp.2021.153474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOTCH1 mutations as prognostic marker in oral squamous cell carcinoma.PMID 33993060Read ↗

Notch1 mutations are drivers of oral tumorigenesis.Semantic proximity Read ↗

Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma.Semantic proximity Read ↗

Genomic landscape of oral squamous cell carcinoma highlights prognostic significance of NOTCH1 mutations and subsite-specific differencesSemantic proximity Read ↗

NOTCH mutations: multiple faces in human malignancies.Semantic proximity Read ↗

Notch1 Mutation Represents a Potential Therapeutic Target to Enhance Immune Recognition in Oral Squamous Cell Carcinoma.Semantic proximity Read ↗

Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities.Semantic proximity Read ↗

A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect.Semantic proximity Read ↗

Role of Mutation of NOTCH1 gene in development of oral squamous cell carcinoma: a narrative review.Semantic proximity Read ↗

The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma.Semantic proximity Read ↗

NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma.Semantic proximity Read ↗

Lessons learned from next-generation sequencing in head and neck cancer.Semantic proximity Read ↗

Notch signaling genes and CD8 + T‐cell dynamics: Their contribution to immune‐checkpoint inhibitor therapy in oral squamous cell carcinoma: A retrospective studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.