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Article

Notch1 Mutation Represents a Potential Therapeutic Target to Enhance Immune Recognition in Oral Squamous Cell Carcinoma.

Cancer reports (Hoboken, N.J.) - 1 Oct 2025

Iwamoto Takahiro, Ogi Kazuhiro, Nakagaki Takafumi, Sasaya Takashi, Miyamoto Sho, Nishiyama Koyo, Sasaki Kenta, Sugita Shintaro, Sasaki Yasushi, Miyazaki Akihiro

Abstract excerpt

BACKGROUND: Notch1, a tumor suppressor gene, is one of the most frequently mutated genes in head and neck squamous cell carcinoma (HNSCC). Therefore, it is clinically important to investigate the effects of Notch1 mutations on antitumor immunity in oral squamous cell carcinoma (OSCC), a subset of HNSCC. AIMS: This study investigated Notch1 mutations and the expression of immune-related proteins. We also examined...

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Share to B7-H1 Antigen
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Lymphocytes, Tumor-Infiltrating

Share to Mouth Neoplasms

Share to Receptor, Notch1

Share to Squamous Cell Carcinoma of Head and Neck

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Source

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Identifiers

PMID: 41026775
DOI: 10.1002/cnr2.70345
PMCID: PMC12483097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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