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Article

Long QT syndrome: ionic basis and arrhythmia mechanism in long QT syndrome type 1.

Journal of cardiovascular electrophysiology - 1 Jun 2000

Sanguinetti M C

Abstract excerpt

Long QT syndrome type 1 (LQT1) causes torsades de pointes arrhythmia, ventricular fibrillation, and sudden death. It usually is inherited as an autosomal dominant trait (Romano-Ward syndrome). The primary defect in LQT1 is a mutation in KVLQT1, a gene that encodes the pore-forming alpha-subunit of a K+ channel. KvLQT1 alpha-subunits coassemble with minK beta-subunits to form channels that conduct the slow delayed...

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Identifiers

PMID: 10868746
DOI: 10.1111/j.1540-8167.2000.tb00035.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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