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Article

Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.

Cardiac electrophysiology clinics - 1 Jun 2016

Wu Wei, Sanguinetti Michael C

Abstract excerpt

Human cardiomyocytes express 3 distinct types of delayed rectifier potassium channels. Human ether-a-go-go-related gene (hERG) channels conduct the rapidly activating current IKr; KCNQ1/KCNE1 channels conduct the slowly activating current IKs; and Kv1.5 channels conduct an ultrarapid activating current IKur. Here the authors provide a general overview of the mechanistic and structural basis of ion selectivity,...

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Identifiers

PMID: 27261821
DOI: 10.1016/j.ccep.2016.01.002
PMCID: PMC4894371

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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