Article

KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3

2024-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Intellectual disability (ID) affects ∼2% of the general population and is often genetic in origin. ID-associated genes are enriched for epigenetic factors, including those encoding the largest family of histone lysine acetyltransferases (KAT5-KAT8). Among them is KAT6A , whose de novo heterozygous mutations cause KAT6A Syndrome (or Arboleda-Tham Syndrome), with ID as a common clinical feature....

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Literature Corpus work: 180553ba-9c9e-5c9c-9981-6f82a9ebc7f2
DOI: 10.1101/2024.03.26.586861

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