Article

A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulation

2025-10-19

Abstract excerpt

Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically defined as the maintenance methyltransferase that preserves DNA methylation patterns during replication, exemplifies this versatility. Beyond its canonical role, DNMT1 is highly expressed in the developing and adult br...

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Literature Corpus work: f62efb1b-2eb2-52ec-a5de-0973d8a5b513
DOI: 10.1101/2025.10.19.683279

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