Article
Neuronal SETD2 activity links microtubule methylation to an anxiety-like phenotype in mice.
Brain : a journal of neurology - 4 Sept 2021
Koenning Matthias, Wang Xianlong, Karki Menuka, Jangid Rahul Kumar, Kearns Sarah, Tripathi Durga Nand, Cianfrocco Michael, Verhey Kristen J, Jung Sung Yun, Coarfa Cristian, Ward Christopher Scott, Kalish Brian Thomas, Grimm Sandra L, Rathmell W Kimryn, Mostany Ricardo, Dere Ruhee, Rasband Matthew Neil, Walker Cheryl Lyn, Park In Young
Abstract excerpt
Gene discovery efforts in autism spectrum disorder have identified heterozygous defects in chromatin remodeller genes, the 'readers, writers and erasers' of methyl marks on chromatin, as major contributors to this disease. Despite this advance, a convergent aetiology between these defects and aberrant chromatin architecture or gene expression has remained elusive. Recently, data have begun to emerge that...
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