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Article

ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum

7 May 2024

Abstract excerpt

Mutations in ARID1B, a member of the mSWI/SNF complex, cause severe neurodevelopmental phenotypes with elusive mechanisms in humans. The most common structural abnormality in the brain of ARID1B patients is agenesis of the corpus callosum (ACC), characterized by the absence of an interhemispheric white matter tract that connects distant cortical regions. Here, we find that neurons expressing SATB2, a determinant...

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PMID: 38718796
DOI: 10.1016/j.stem.2024.04.014

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