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Article

The role of polygenic risk and susceptibility genes in breast cancer over the course of life.

Nature communications - 14 Dec 2020

Mars Nina, Widén Elisabeth, Kerminen Sini, Meretoja Tuomo, Pirinen Matti, Della Briotta Parolo Pietro, Palta Priit, Palotie Aarno, Kaprio Jaakko, Joensuu Heikki, Daly Mark, Ripatti Samuli

Abstract excerpt

Polygenic risk scores (PRS) for breast cancer have potential to improve risk prediction, but there is limited information on their utility in various clinical situations. Here we show that among 122,978 women in the FinnGen study with 8401 breast cancer cases, the PRS modifies the breast cancer risk of two high-impact frameshift risk variants. Similarly, we show that after the breast cancer diagnosis, individuals...

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Identifiers

PMID: 33318493
DOI: 10.1038/s41467-020-19966-5
PMCID: PMC7736877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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