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Polygenic risk score is associated with increased disease risk in 52 Finnish breast cancer families.

Breast cancer research and treatment - 1 Aug 2016

Muranen Taru A, Mavaddat Nasim, Khan Sofia, Fagerholm Rainer, Pelttari Liisa, Lee Andrew, Aittomäki Kristiina, Blomqvist Carl, Easton Douglas F, Nevanlinna Heli

Abstract excerpt

The risk of developing breast cancer is increased in women with family history of breast cancer and particularly in families with multiple cases of breast or ovarian cancer. Nevertheless, many women with a positive family history never develop the disease. Polygenic risk scores (PRSs) based on the risk effects of multiple common genetic variants have been proposed for individual risk assessment on a population...

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Identifiers

PMID: 27438779
DOI: 10.1007/s10549-016-3897-6
PMCID: PMC4963452

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