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Article

Polygenic risk score and its role in cancer susceptibility.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti - 1 Jan 2026

Mišove A, Macháčková E, Nováková K, Svoboda M

Abstract excerpt

BACKGROUND: Polygenic risk score (PRS) has the ability to stratify inherited susceptibility to cancer and, as a complement to monogenic testing, can identify individuals at increased genetic risk even when no pathogenic variant is detected in high- or moderate-penetrance genes. It reflects the combined additive effects of a large number of low-penetrance variants across the genome, and represents a continuum of...

Read the complete abstract on PubMed

Topics

Humans
Genetic Risk Score
Genetic Predisposition to Disease
Neoplasms
Genetic Testing
Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 42692837
DOI: 10.48095/ccko2026S12

Genes

ATM
CHEK2

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