Article
Association and performance of polygenic risk scores for breast cancer among French women presenting or not a familial predisposition to the disease.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2023
Jiao Yue, Truong Thérèse, Eon-Marchais Séverine, Mebirouk Noura, Caputo Sandrine M, Dondon Marie-Gabrielle, Karimi Mojgan, Le Gal Dorothée, Beauvallet Juana, Le Floch Édith, Dandine-Roulland Claire, Bacq-Daian Delphine, Olaso Robert, Albuisson Juliette, Audebert-Bellanger Séverine, Berthet Pascaline, Bonadona Valérie, Buecher Bruno, Caron Olivier, Cavaillé Mathias, Chiesa Jean, Colas Chrystelle, Collonge-Rame Marie-Agnès, Coupier Isabelle, Delnatte Capucine, De Pauw Antoine, Dreyfus Hélène, Fert-Ferrer Sandra, Gauthier-Villars Marion, Gesta Paul, Giraud Sophie, Gladieff Laurence, Golmard Lisa, Lasset Christine, Lejeune-Dumoulin Sophie, Léoné Mélanie, Limacher Jean-Marc, Lortholary Alain, Luporsi Élisabeth, Mari Véronique, Maugard Christine M, Mortemousque Isabelle, Mouret-Fourme Emmanuelle, Nambot Sophie, Noguès Catherine, Popovici Cornel, Prieur Fabienne, Pujol Pascal, Sevenet Nicolas, Sobol Hagay, Toulas Christine, Uhrhammer Nancy, Vaur Dominique, Venat Laurence, Boland-Augé Anne, Guénel Pascal, Deleuze Jean-François, Stoppa-Lyonnet Dominique, Andrieu Nadine, Lesueur Fabienne
Abstract excerpt
BACKGROUND: Three partially overlapping breast cancer polygenic risk scores (PRS) comprising 77, 179 and 313 SNPs have been proposed for European-ancestry women by the Breast Cancer Association Consortium (BCAC) for improving risk prediction in the general population. However, the effect of these SNPs may vary from one country to another and within a country because of other factors. OBJECTIVE: To assess their...
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