Article

Polygenic risk, susceptibility genes, and breast cancer over the life course

2020-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Polygenic risk scores (PRS) for breast cancer have potential to improve risk prediction, but there is limited information on their clinical applicability. We set out to study how PRS could help in clinical decision making. Among 99,969 women in the FinnGen study with 6,879 breast cancer cases, the PRS was associated not only with breast cancer incidence but also with a range of breast cancer-rel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bda69329-a456-5d40-b015-263ae24926e0
DOI: 10.1101/2020.04.17.20069229

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk, susceptibility genes, and breast cancer over the life courseDOI 10.1101/2020.04.17.20069229Read

The role of polygenic risk and susceptibility genes in breast cancer over the course of life.Semantic proximity Read

Polygenic Risk Scores for Breast Cancer: Modern Approaches to Risk Prediction and Subtype Identification.Semantic proximity Read

Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women.Semantic proximity Read

Association and performance of polygenic risk scores for breast cancer among French women presenting or not a familial predisposition to the disease.Semantic proximity Read

Association of a Polygenic Risk Score With Breast Cancer Among Women Carriers of High- and Moderate-Risk Breast Cancer Genes.Semantic proximity Read

Development of a Breast Cancer Risk Prediction Model Integrating Monogenic, Polygenic, and Epidemiologic Risk.Semantic proximity Read

Segregation analysis of 17,425 population-based breast cancer families: evidence for genetic susceptibility and risk predictionSemantic proximity Read

Polygenic risk scores to refine Breast cancer screening and prevention strategies.Semantic proximity Read

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors.Semantic proximity Read

Polygenic risk score (PRS) and its potential for breast cancer risk stratification.Semantic proximity Read

Genomic risk prediction for breast cancer in older womenSemantic proximity Read

Genetic assessments of breast cancer risk that do not account for polygenic background are incomplete and lead to incorrect preventative strategiesSemantic proximity Read