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Article

The mutational pattern of homologous recombination (HR)-associated genes and its relevance to the immunotherapeutic response in gastric cancer.

Cancer biology & medicine - 15 Nov 2020

Fan Yue, Ying Haifeng, Wu Xueying, Chen Huan, Hu Ying, Zhang Henghui, Wu Lijia, Yang Ying, Mao Beibei, Zheng Lan

Abstract excerpt

Objective: Currently, there is an urgent need to identify immunotherapeutic biomarkers to increase the benefit of immune checkpoint inhibitors (ICIs) for patients with gastric cancer (GC). Homologous recombination deficiency (HRD) can modify the tumor immune microenvironment by increasing the presence of tumor-infiltrating lymphocytes and therefore might serve as a biomarker of immunotherapeutic response. We...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33299649
DOI: 10.20892/j.issn.2095-3941.2020.0089
PMCID: PMC7721103

Genes

GC
IMPACT
ATM

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