Article
The mutational pattern of homologous recombination repair genes in urothelial carcinoma and its correlation with immunotherapeutic response.
Cancer medicine - 1 Dec 2023
Chen Junru, Tang Yanfeng, Liu Huanhuan, Sun Guangxi, Liu Haoyang, Zhao Junjie, Wang Zilin, Zhang Yanrui, Lou Feng, Cao Shanbo, Qin Jiayue, Wang Huina, Liao Banghua, Zeng Hao
Abstract excerpt
BACKGROUND: The mutational pattern of homologous recombination repair (HRR)-associated gene alterations in Chinese urothelial carcinoma (UC) necessitates comprehensive sequencing efforts, and the clinical implications of HRR gene mutations in UC remain to be elucidated. MATERIALS AND METHODS: We delineated the mutational landscape of 343 Chinese UC patients from West China Hospital and 822 patients from The...
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