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MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity

18 Nov 2020

Abstract excerpt

Defective IFN production and exacerbated inflammatory and pro-fibrotic responses are hallmarks of SARS-CoV-2 infection in severe COVID-19. Based on these hallmarks, and considering the pivotal role of macrophages in COVID-19 pathogenesis, we hypothesize that the transcription factors MAFB and MAF critically contribute to COVID-19 progression by shaping the response of macrophages to SARS-CoV-2. Our proposal stems...

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PMID: 33312178
DOI: 10.3389/fimmu.2020.603507

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