Article
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Cell - 22 Dec 2021
Wendisch Daniel, Dietrich Oliver, Mari Tommaso, von Stillfried Saskia, Ibarra Ignacio L, Mittermaier Mirja, Mache Christin, Chua Robert Lorenz, Knoll Rainer, Timm Sara, Brumhard Sophia, Krammer Tobias, Zauber Henrik, Hiller Anna Luisa, Pascual-Reguant Anna, Mothes Ronja, Bülow Roman David, Schulze Jessica, Leipold Alexander M, Djudjaj Sonja, Erhard Florian, Geffers Robert, Pott Fabian, Kazmierski Julia, Radke Josefine, Pergantis Panagiotis, Baßler Kevin, Conrad Claudia, Aschenbrenner Anna C, Sawitzki Birgit, Landthaler Markus, Wyler Emanuel, Horst David, Hippenstiel Stefan, Hocke Andreas, Heppner Frank L, Uhrig Alexander, Garcia Carmen, Machleidt Felix, Herold Susanne, Elezkurtaj Sefer, Thibeault Charlotte, Witzenrath Martin, Cochain Clément, Suttorp Norbert, Drosten Christian, Goffinet Christine, Kurth Florian, Schultze Joachim L, Radbruch Helena, Ochs Matthias, Eils Roland, Müller-Redetzky Holger, Hauser Anja E, Luecken Malte D, Theis Fabian J, Conrad Christian, Wolff Thorsten, Boor Peter, Selbach Matthias, Saliba Antoine-Emmanuel, Sander Leif Erik
Abstract excerpt
COVID-19-induced "acute respiratory distress syndrome" (ARDS) is associated with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury remains incompletely understood. Here, we analyze pulmonary immune responses and lung pathology in two cohorts of patients with COVID-19 ARDS using functional single-cell genomics, immunohistology, and electron microscopy. We describe an...
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