Article
Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2018
Kikuchi Kenta, Iida Mayumi, Ikeda Naoki, Moriyama Shigetaka, Hamada Michito, Takahashi Satoru, Kitamura Hiroshi, Watanabe Takashi, Hasegawa Yoshinori, Hase Koji, Fukuhara Takeshi, Sato Hideyo, Kobayashi Eri H, Suzuki Takafumi, Yamamoto Masayuki, Tanaka Masato, Asano Kenichi
Abstract excerpt
Macrophages manifest distinct phenotype according to the organs in which they reside. In addition, they flexibly switch their character in adaptation to the changing environment. However, the molecular basis that explains the conversion of the macrophage phenotype has so far been unexplored. We find that CD169+ macrophages change their phenotype by regulating the level of a transcription factor Maf both in vitro...
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